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For example, Lactobacillus johnsonii reduces circulating KYN and intestinal IDO activity in rats [185], Bifidobacterium infantis increases plasma TRP and KYNA in male rats [186], and probiotic supplementation in humans lowers plasma KYN while increasing TRP levels [187]

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Solvent A contained isopropanol/hexane/water (285:215:5, v/v/v), and solvent B contained isopropanol/hexane/water (285:215:40, v/v/v)